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Maybe not the worst case of flanderisation, but Britta in Community comes to mind.
Jeff even lampshades it. “You seemed smarter when I met you.”
Is it my imagination, or did Joey from Friends get increasingly more dumb as the series progressed? He started out as a goofball but reliable friend who was prone to misunderstanding, but for the spinoff he was borderline institution material who couldn’t hold a job.
Brooklyn 99 had a few examples but the most egregious in my opinion was Gina.